Synthetic biology is an increasingly high‐profile area of research that can be understood as encompassing three broad approaches towards the synthesis of living systems: DNA‐based device construction, genome‐driven cell engineering and protocell creation. Each approach is characterized by different aims, methods and constructs, in addition to a range of positions on intellectual property and regulatory regimes. We identify subtle but important differences between the schools in relation to their treatments of genetic determinism, cellular context and complexity. These distinctions tie into (...) two broader issues that define synthetic biology: the relationships between biology and engineering, and between synthesis and analysis. These themes also illuminate synthetic biology's connections to genetic and other forms of biological engineering, as well as to systems biology. We suggest that all these knowledge‐making distinctions in synthetic biology raise fundamental questions about the nature of biological investigation and its relationship to the construction of biological components and systems. BioEssays 30:57–65, 2008. © 2007 Wiley Periodicals, Inc. (shrink)

Vagueness in law leads to indeterminacies in legal rights and obligations in many cases. The book defends that claim and explains its implications for legal theory. Vague language is the book's focus, but vagueness is not merely a linguistic feature of law. Law is necessarily vague. That fact seems to threaten the coherence of the ideal of the rule of law. The book defends a new, coherent articulation of that ideal.

Looks into evaluation of information provision probability from different sources, based on use of linguistic variables. Formation of functions appurtenant for its unclear variables provides for adoption of decisions by the decision maker, in conditions of nonprobabilistic equivocation. The development of market relations in Ukraine increases the independence and responsibility of enterprises in justifying and making management decisions that ensure their effective, competitive activities. As a result of the analysis, it is determined that the condition of economic facilities can be (...) described and determined by the decision-maker, in the presence of the necessary information. The confidence of the decision-maker in the information received is different and the decisions made have a correspondingly different level of information risk. It is important to substantiate the procedure for assessing the numerical extent of information risk in decision-making based on the information obtained in conditions of uncertainty. The use of a linguistic variable in the processing of expert data presented in the form of a matrix of binary relations of values of the membership function, which allowed to move to further processing of knowledge to support decision-making in the management of industrial, commercial, financial and other activities. As a mathematical model for estimating the numerical measure of information risk when making decisions based on the information obtained in conditions of non-stochastic uncertainty, a model has been developed to model natural language uncertainties, which differs from existing ones by formalizing knowledge taking into account uncertainty of input information. Making such a clear decision in a fuzzy environment has appropriate values of effectiveness and risk. The paper proposes all the functions and accessories of indicators of both quantitative nature and qualitative nature to bring their values in the field of definition to one scale. Then the indicator of the effectiveness of decision-making will be a measure of the clarity of the cross-section of fuzzy subsets, which correspond to the introduced indicators of information risk. The condition of economic facilities can be described and determined by the decision-maker, if the necessary information is available. Decision-making on thenumerical measure of information risk must be determined by a set of basic indicators, which can be both quantitative and qualitative in nature. Predictive values of indicators should be determined in conditions of nonstochastic uncertainty. In this case, the indicators of a quantitative nature can be determined by fuzzy triangular numbers, which implement a high level of confidence in the subjective judgments of experts. Indicators of qualitative nature should be presented in linguistic variables. The values of the indicators of qualitative nature that are predicted must be considered for all fuzzy variable terms-sets of linguistic variables introduced into consideration. For any fuzzy variable, the introduction to the consideration of a clear set of values as carriers of the α-level of its membership function allows to reduce to a single interpretation of the predicted values of indicators of quantitative and qualitative nature in terms of non-stochastic uncertainty. (shrink)

Diese Arbeit zeigt, dass die Dualität des mathematischen und dynamischen Erhabenen bei Kant auch dem Zweck der dritten Kritik dient, die Kluft zwischen den Gebieten der Natur und der Freiheit zu schließen. In der Sekundärliteratur zu Kant wird das Erhabene oft als Anhang des Schönen oder aufgrund seiner mehrfachen Dualitäten als Bruch in Kants Ansatz angesehen. Dies geschieht, weil solche Interpretationen die Elemente der Theorie des Erhabenen atomisch und nicht systematisch rekonstruieren. Im Gegensatz dazu wird in dieser Arbeit mittels der (...) Resonanz der teleologischen Behandlung der Vernunft nicht nur die innere Systematik der dritten Kritik gezeigt, sondern auch die von der gesamten kritischen Philosophie. Die Vernunft als Vermögen der Zwecksetzung zu verstehen in ihrem praktischen und theoretischen Gebrauch, ist keine neue Idee oder neuer systematischer Rekonstruktionsversuch der kritischen Philosophie in der Kantforschung. Das eigentlich Neue in dieser Monografie ist, einen Beweis von ihrer teleologischen Einheit aus der ästhetischen Perspektive des paradoxen Gefühls des Erhabenen geleistet zu haben. (shrink)

Open peer commentary on the article “Designing Academic Conferences in the Light of Second-Order Cybernetics” by Laurence D. Richards. Upshot: I propose that a lack of a common ground or culture of understanding is a design flaw in academic conferences that creates opportunities for violent reactions. I suggest that an additional or revised design principle or praxis should be considered through application of second-order cybernetics.

The study investigated the influence of campus environmental factors on job commitments. The research design was quantitative descriptive sample survey of ex-post facto type while the population includes both male and female senior non-teaching staff of Olabisi Onabanjo University, Ogun State. Multi-stage sampling technique was used in choosing 200 participants selected from nine faculties and one college. A structured and close-ended questionnaire titled ‘Campus Environmental Factors and Job Commitment Questionnaire’ with reliability co-efficient of 0.85 obtained through Cronbach alpha methods was (...) administered. 170 were retrieved from the 200 instruments administered. Data were analysed using frequency count, simple percentage, Pearson Correlation, and t test of significance. The study demonstrated a significant positive influence of campus environmental factors on job commitments of staff in the university. Useful recommendations were also raised. (shrink)

v. 1 Na antiguidade e na Idade Média.--v. 2. A civilização do homem-exterior.

When looking at a scene, observers feel that they see its entire structure in great detail and can immediately notice any changes in it. However, when brief blank fields are placed between alternating displays of an original and a modified scene, a striking failure of perception is induced: identification of changes becomes extremely difficult, even when changes are large and made repeatedly. Identification is much faster when a verbal cue is provided, showing that poor visibility is not the cause of (...) this difficulty. Identification is also faster for objects mentioned in brief verbal descriptions of the scene. These results support the idea that observers never form a complete, detailed representation of their surroundings. In addition, results also indicate that attention is required to perceive change, and that in the absence of localized motion signals it is guided on the basis of high-level interest. (shrink)

The subject of this paper is the integrity of nature over time—‘diachronic integrity’. The argument of the parer is that any serious attempt to address conservation problems—the kinds of problems faced by environmental managers the world over, needs to operate with an eye to some principle of diachronic integrity. Whilst acknowledging that applying the principle is largely a matter of experience and judgement, we argue that it applies equally both to human and to natural history.

A model representing isotope separation during water evaporation in plants was constructed. The model accounts for substance diffusion, convective transfer and evaporation from the surface of the leaves. The dependence of the system’s separation and enrichment coefficients on various parameters was determined. A comparison was made between the enrichment coefficients calculated from experimental data from different plants and those based on the model. Qualitative agreement between the experimental and theoretical values was obtained for the case of $$\frac{uh}{D} {\gg} 1$$ uh (...) D ≫ 1, where u is the average velocity of water in the plant, h is the height of the plant, and D is the diffusion coefficient of the substance. (shrink)

The purpose of the study is to determine the key strategies of philosophical criticism of Heidegger’s Black Notebooks, whose achievement is realized in the following tasks: 1) to identify the body of texts that represent the discourse of philosophical criticism of Heidegger notes; 2) to reveal the typological features of the different strategies of interpreting Black Notebooks; 3) to reconstruct a thematic horizon of Heidegger studies, opened up by discussion on published notes. The methodology combines elements of discourse analysis with (...) traditional methods of historical and philosophical criticism. Scientific novelty is expressed in the following: 1) philosophical discourse of the Notebooks’ reception includes texts of narrowly specialized character, as well as reflections of key philosophers 2) basic strategies in philosophical critique of Black Notebooks convey the overall structure of the discourse of interpretation of Heidegger’s legacy, distributed between apologetics and ideological criticism; 3) Black Notebooks have exacerbated the problem of architectonics of Gesammtausgabe and formed the textual basis for the study of "silence" period in philosophical life of Heidegger. Conclusions. The discourse of philosophical critique of Heidegger’s notes proves evidence for ideological charge of philosophizing and justifies socially oriented approaches of historical and philosophical studies examining philosophizing as a special cultural practice, not as a form of sublime creativity. (shrink)

The purpose of the study is to determine the key strategies of philosophical criticism of Heidegger’s Black Notebooks, whose achievement is realized in the following tasks: 1) to identify the body of texts that represent the discourse of philosophical criticism of Heidegger notes; 2) to reveal the typological features of the different strategies of interpreting Black Notebooks; 3) to reconstruct a thematic horizon of Heidegger studies, opened up by discussion on published notes. The methodology combines elements of discourse analysis with (...) traditional methods of historical and philosophical criticism. Scientific novelty is expressed in the following: 1) philosophical discourse of the Notebooks’ reception includes texts of narrowly specialized character, as well as reflections of key philosophers 2) basic strategies in philosophical critique of Black Notebooks convey the overall structure of the discourse of interpretation of Heidegger’s legacy, distributed between apologetics and ideological criticism; 3) Black Notebooks have exacerbated the problem of architectonics of Gesammtausgabe and formed the textual basis for the study of "silence" period in philosophical life of Heidegger. Conclusions. The discourse of philosophical critique of Heidegger’s notes proves evidence for ideological charge of philosophizing and justifies socially oriented approaches of historical and philosophical studies examining philosophizing as a special cultural practice, not as a form of sublime creativity. (shrink)